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Does the replacement gene for gene therapy actually rid of the body of the gene it's meant to replace?
Yes it does hence the word replacement.
The way modern curative gene therapy is done is to modify a vies and then use the virus to infect the specific gene. The virus makes a modified version of the gene that is corrected for the genetic error. As the virus infects the target creature and continues then it replaces most of the genes. As the body's cells die and are replaced the old flawed gene is removed from the gene pool and the target creature is totally cured AND it will not pass on the faulty gene to its young.
According to Wikipedia: http://en.wikipedia.org/wiki/Gene_therapy
"Gene therapy is the insertion of genes into an individual's cells and tissues to treat a disease, and hereditary diseases in which a defective mutant allele is replaced with a functional one. Although the technology is still in its infancy, it has been used with some success....
In most gene therapy studies, a "corrected" gene is inserted into the genome to replace an "abnormal," disease-causing gene. A carrier called a vector must be used to deliver the therapeutic gene to the patient's target cells. Currently, the most common type of vectors are viruses that have been genetically altered to carry normal human DNA. Viruses have evolved a way of encapsulating and delivering their genes to human cells in a pathogenic manner. Scientists have tried to harness this ability by manipulating the viral genome to remove disease-causing genes and insert therapeutic ones.
Target cells such as the patient's liver or lung cells are infected with the vector. The vector then unloads its genetic material containing the therapeutic human gene into the target cell. The generation of a functional protein product from the therapeutic gene restores the target cell to a normal state."
Mike A is wrong about gene replacement that is the entire idea. Yes there are therapies that change the 'expression of the gene' and so switch it on if it is not producing, but if the body is not producing a vital clotting agent then the gene that will produce that vital clotting agent is replaced so that it will be produced.
There are other ways to target the genes and to try and replace specific strands of DNA or RNA, but the basic idea is to replace the flawed gene.
